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Neuron. 2009 Oct 29;64(2):267-80. doi: 10.1016/j.neuron.2009.08.037.

Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop.

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1
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA.

Abstract

Theta oscillations are believed to play an important role in the coordination of neuronal firing in the entorhinal (EC)-hippocampal system but the underlying mechanisms are not known. We simultaneously recorded from neurons in multiple regions of the EC-hippocampal loop and examined their temporal relationships. Theta-coordinated synchronous spiking of EC neuronal populations predicted the timing of current sinks in target layers in the hippocampus. However, the temporal delays between population activities in successive anatomical stages were longer (typically by a half theta cycle) than expected from axon conduction velocities and passive synaptic integration of feed-forward excitatory inputs. We hypothesize that the temporal windows set by the theta cycles allow for local circuit interactions and thus a considerable degree of computational independence in subdivisions of the EC-hippocampal loop.

PMID:
19874793
PMCID:
PMC2771122
DOI:
10.1016/j.neuron.2009.08.037
[Indexed for MEDLINE]
Free PMC Article
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