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J Biol. 2009;8(10):92. doi: 10.1186/jbiol184.

Mechanisms of ubiquitin transfer by the anaphase-promoting complex.

Author information

1
Department of Physiology, University of California, San Francisco, CA 94158, USA.

Abstract

The anaphase-promoting complex (APC) is a ubiquitin-protein ligase required for the completion of mitosis in all eukaryotes. Recent mechanistic studies reveal how this remarkable enzyme combines specificity in substrate binding with flexibility in ubiquitin transfer, thereby allowing the modification of multiple lysines on the substrate as well as specific lysines on ubiquitin itself.

PMID:
19874575
PMCID:
PMC2790831
DOI:
10.1186/jbiol184
[Indexed for MEDLINE]
Free PMC Article

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