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Curr Alzheimer Res. 2009 Oct;6(5):419-23.

A neurotrophic rationale for the therapy of neurodegenerative disorders.

Author information

1
Pharmacology and Therapeutics, The Lady Davis Institute, Jewish General Hospital, University of Montréal, Montréal, Québec, Canada. Uri.Saragovi@mcgill.ca

Abstract

The concept and rationale for neuroprotection are presented. Several examples of small molecule neurotrophic agents with favourable drug-like and pharmacological properties are shown. Compound efficacy in acute neurodegenerative models (optic nerve axotomy) and chronic neurodegenerative models (glaucoma, age-associated cognitive impairment, Alzheimer's Disease) are evaluated and discussed. Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing.

PMID:
19874265
DOI:
10.2174/156720509789207912
[Indexed for MEDLINE]

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