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J Exp Med. 1947 Mar 31;85(4):365-71.

IMPAIRMENT OF ANTIBODY RESPONSE IN PYRIDOXINE-DEFICIENT RATS.

Author information

1
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York.

Abstract

Striking impairment of the antibody response to sheep erythrocytes was found in pyridoxine-deficient rats. Deficiencies in the three other B factors required by the rat, and low protein feeding, having effects on body weight comparable to pyridoxine deficiency, failed to influence the antibody response studied. Confirming previous observations, a striking loss of thymic and lymphoid tissue occurred in the pyridoxine-deficient animals. A marked deficit in thymus weight also resulted from the feeding of a diet low in thiamin. Histologically, however, lymphoid atrophy was less pronounced in thiamin-deficient rats than in those deprived of pyridoxine.

PMID:
19871621
PMCID:
PMC2135611
[Indexed for MEDLINE]
Free PMC Article

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