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Biochem Pharmacol. 1991 Jan 1;41(1):115-8.

A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.

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1
Department of Biochemistry, Tokushima University School of Medicine, Japan.

Abstract

Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM). Arachidonate 12-lipoxygenase purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the compound only at higher concentrations (IC50 = 2.3, 11, 5.2 and 2.5 microM, respectively).

PMID:
1986735
DOI:
10.1016/0006-2952(91)90018-z
[Indexed for MEDLINE]

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