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Org Biomol Chem. 2009 Nov 21;7(22):4567-81. doi: 10.1039/b913066g. Epub 2009 Oct 1.

1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents.

Author information

1
Departamento de Química Orgánica and Instituto de Síntesis Orgánica, Facultad de Ciencias, Universidad de Alicante, 03080-Alicante, Spain. cnajera@ua.es

Abstract

In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.

PMID:
19865689
DOI:
10.1039/b913066g
[Indexed for MEDLINE]

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