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Leuk Lymphoma. 2009 Oct;50(10):1661-5.

Multicentric plasmocytic Castleman's disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection--a possible relationship.

Author information

1
Third Department of Internal Medicine, Semmelweis University, Budapest, Hungary.

Erratum in

  • Leuk Lymphoma. 2009 Dec;50(12):2101.

Abstract

Authors report a case of Castleman's disease (CD) with polyneuropathy, organomegaly, endocrinopathy, M protein, skin change (POEMS) syndrome. According to the present knowledge, these two rare conditions are often induced by Human Herpes Vírus- 8 (HHV-8) or by Human Immunodefeciency Virus, separately or in combination. In this case, however, HHV-6 viral DNA had been detected in the blood and lymph node samples by PCR. The authors conclude that the modulation of immune functions by HHV-6 might be responsible for the development of CD and POEMS syndrome in the referred case.

PMID:
19863339
[Indexed for MEDLINE]

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