Bromodecarboxylation of quinoline salicylic acids: increasing the diversity of accessible substituted quinolines

J Org Chem. 2009 Nov 20;74(22):8874-7. doi: 10.1021/jo9018232.

Abstract

Quinoline salicylic acids underwent bromodecarboxylation at room temperature upon treatment with N-bromosuccinimide. A wide variety of functional groups was tolerated. Several one-pot transformations were also carried out, allowing the preparation of diverse 4-substituted quinolines.

MeSH terms

  • Decarboxylation
  • Molecular Structure
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry*
  • Salicylates / chemistry*
  • Stereoisomerism

Substances

  • Quinolines
  • Salicylates