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Mutat Res. 1991 Jan;262(1):37-40.

A case of spontaneous trisomy in the spermatocytes of Microtus arvalis.

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Institute of Cytology and Genetics, Academy of Sciences of the U.S.S.R. Siberian Department, Novosibirsk.


A triple synaptomal complex was observed between 3 small-sized chromosomes in 4 spermatocytes closely connected by intercellular bridges, of the common vole (Microtus arvalis L.). Other spermatocytes from the same and from 2 other males had a normal chromosome complement and pairing patterns. This finding was interpreted as the result of a single act of non-disjunction taking place in a spermatogonium. These data suggest that chromosome non-disjunction in premeiotic germ cells can be considered one of the causes of aneuploidy in mammals.

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