Format

Send to

Choose Destination
See comment in PubMed Commons below
Magn Reson Med. 2009 Dec;62(6):1497-509. doi: 10.1002/mrm.22132.

High-contrast in vivo visualization of microvessels using novel FeCo/GC magnetic nanocrystals.

Author information

1
Department of Electrical Engineering, Stanford University, Stanford, California 94305-5080, USA.

Erratum in

  • Magn Reson Med. 2010 Jun;63(6):1723.

Abstract

FeCo-graphitic carbon shell nanocrystals are a novel MRI contrast agent with unprecedented high per-metal-atom-basis relaxivity (r(1) = 97 mM(-1) sec(-1), r(2) = 400 mM(-1) sec(-1)) and multifunctional capabilities. While the conventional gadolinium-based contrast-enhanced angiographic magnetic MRI has proven useful for diagnosis of vascular diseases, its short circulation time and relatively low sensitivity render high-resolution MRI of morphologically small vascular structures such as those involved in collateral, arteriogenic, and angiogenic vessel formation challenging. Here, by combining FeCo-graphitic carbon shell nanocrystals with high-resolution MRI technique, we demonstrate that such microvessels down to approximately 100 mum can be monitored in high contrast and noninvasively using a conventional 1.5-T clinical MRI system, achieving a diagnostic imaging standard approximating that of the more invasive X-ray angiography. Preliminary in vitro and in vivo toxicity study results also show no sign of toxicity.

PMID:
19859938
PMCID:
PMC2824553
DOI:
10.1002/mrm.22132
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center