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Nat Rev Nephrol. 2009 Dec;5(12):691-700. doi: 10.1038/nrneph.2009.185. Epub 2009 Oct 27.

Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism.

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Department of Internal Medicine, Division of Nephrology, University Medical Centre Groningen, University of Groningen, The Netherlands.


Vitamin D is typically viewed as a key player in the regulation of calcium and phosphate levels and the control of bone metabolism; however, growing evidence suggests that vitamin D deficiency may also have an important role in the progressive loss of renal function. Vitamin D deficiency is particularly frequent in patients with chronic kidney disease, in whom it is associated with increased mortality. Studies indicate that treatment with vitamin D analogues reduces proteinuria, suppresses the renin-angiotensin-aldosterone system (RAAS), and exerts anti-inflammatory and immunomodulatory effects. These pleiotropic effects render vitamin D a potentially interesting treatment modality for renoprotection in patients with chronic kidney disease. Whether vitamin D has clinically relevant renoprotective effects in addition to RAAS blockade is currently under investigation.

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