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Nat Rev Immunol. 2009 Oct;9(10):692-703. doi: 10.1038/nri2634.

Transcriptional control of the inflammatory response.

Author information

1
Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA. ruslan.medzhitov@yale.edu

Abstract

Inflammation is a multicomponent response to tissue stress, injury and infection, and a crucial point of its control is at the level of gene transcription. The inducible inflammatory gene expression programme--such as that triggered by Toll-like receptor signalling in macrophages--is comprised of several coordinately regulated sets of genes that encode key functional programmes; these are controlled by three classes of transcription factors, as well as various transcriptional co-regulators and chromatin modifications. Here, we discuss the mechanisms of and the emerging principles in the transcriptional regulation of inflammatory responses in diverse physiological settings.

PMID:
19859064
DOI:
10.1038/nri2634
[Indexed for MEDLINE]

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