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Pediatr Infect Dis J. 2010 Jan;29(1):79-82. doi: 10.1097/INF.0b013e3181b21040.

Therapeutic drug monitoring of lopinavir in human immunodeficiency virus-infected children receiving adult tablets.

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1
HIVNAT, Thai red cross AIDS Research center, Bangkok, Thailand.

Abstract

Because of the lack of a lopinavir/ritonavir (LPV/r) pediatric formulation, 54 HIV-infected children were given generic LPV/r adult tablets. Of 54 children, 21 took cut pills to get the appropriate dose. The median (interquartile range) LPV trough serum concentration (C trough) was 6.7 (5.0-9.9) mg/L. All the children had C trough >1.0 mg/L and 96% had values >4.0 mg/L. LPV/r adult tablets can be used in children when it is necessary.

PMID:
19858772
DOI:
10.1097/INF.0b013e3181b21040
[Indexed for MEDLINE]
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