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J Magn Reson Imaging. 2009 Nov;30(5):1215-22. doi: 10.1002/jmri.21957.

T1 independent, T2* corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom.

Author information

1
Department of Radiology, University of Wisconsin, Madison, Wisconsin 53792-3252, USA.

Abstract

PURPOSE:

To validate a T(1)-independent, T(2)*-corrected fat quantification technique that uses accurate spectral modeling of fat using a homogeneous fat-water-SPIO phantom over physiologically expected ranges of fat percentage and T(2)* decay in the presence of iron overload.

MATERIALS AND METHODS:

A homogeneous gel phantom consisting of vials with known fat-fractions and iron concentrations is described. Fat-fraction imaging was performed using a multiecho chemical shift-based fat-water separation method (IDEAL), and various reconstructions were performed to determine the impact of T(2)* correction and accurate spectral modeling. Conventional two-point Dixon (in-phase/out-of-phase) imaging and MR spectroscopy were performed for comparison with known fat-fractions.

RESULTS:

The best agreement with known fat-fractions over the full range of iron concentrations was found when T(2)* correction and accurate spectral modeling were used. Conventional two-point Dixon imaging grossly underestimated fat-fraction for all T(2)* values, but particularly at higher iron concentrations.

CONCLUSION:

This work demonstrates the necessity of T(2)* correction and accurate spectral modeling of fat to accurately quantify fat using MRI.

PMID:
19856457
PMCID:
PMC3205952
DOI:
10.1002/jmri.21957
[Indexed for MEDLINE]
Free PMC Article

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