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Pediatr Blood Cancer. 2010 Feb;54(2):311-5. doi: 10.1002/pbc.22294.

Adipocytokines in relation to Hodgkin lymphoma in children.

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Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece.


This case-control study aims to explore the association of serum adiponectin/leptin with childhood Hodgkin lymphoma (HL). Study participants were 75 children with histologically confirmed HL, registered in the Nationwide Registry for Childhood Haematological Malignancies and 75 age- and gender-matched controls. Multiple conditional logistic regression analyses were performed, adjusting for sociodemographic and lifestyle parameters. Adiponectin levels were consistently higher among cases in all models with ORs >1.25; 95% CIs ranging from 0.9 to 1.8 and P-values from 0.09 to 0.20. By contrast, there was no association of serum leptin with HL. In conclusion, elevated serum adiponectin might be a risk factor for childhood HL.

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