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Cell Cycle. 2009 Nov 15;8(22):3688-94. Epub 2009 Nov 24.

Covalent modifications of histones during mitosis and meiosis.

Author information

1
Department of Environmental Medicine, New York University Langone Medical Center, Tuxedo, NY, USA.

Abstract

Higher order chromosome structures are the hallmark of mitotic and meiotic cells. Chromatin condensation and compaction are essential for rapid chromosome congression and accurate chromosome segregation during cell division. The core histones possess tails at their amino-termini. These tails, which extend from the surface of the nucleosomes, are highly dynamic and subject to an extensive array of covalent modifications. Modified histone tails play an important role, not only in the folding of nucleosomal arrays into higher order chromatin structures but also in gene regulation. The combination of these distinct covalent modifications of histones constitutes "the histone code" that regulates various cellular processes, including mitotic and meiotic progression.

PMID:
19855177
DOI:
10.4161/cc.8.22.9908
[Indexed for MEDLINE]

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