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Cell Cycle. 2009 Nov 15;8(22):3695-701. Epub 2009 Nov 27.

ATX-LPA receptor axis in inflammation and cancer.

Author information

1
Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

Abstract

Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G protein-coupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic mice expressing either an LPA receptor or ATX, we recently demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation, further validating the ATX-LPA receptor axis as a rich therapeutic target in cancer.

PMID:
19855166
PMCID:
PMC4166520
DOI:
10.4161/cc.8.22.9937
[Indexed for MEDLINE]
Free PMC Article

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