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Leuk Res. 2010 Aug;34(8):1052-6. doi: 10.1016/j.leukres.2009.09.018. Epub 2009 Oct 23.

The apoptotic and anti-proliferative activity of Origanum majorana extracts on human leukemic cell line.

Author information

1
Department of Biology, University of Balamand, Al-Koura, Lebanon. rabdelmassih@balamand.edu.lb

Abstract

Scientists are constantly searching for phytochemicals and compounds with anti-cancer and antioxidant activity. In this study, the anti-proliferative activity of plant extracts from Origanum majorana (marjoram) was tested on human lymphoblastic leukemia cell line Jurkat. Cytotoxicity was examined using non-radioactive cytotoxicity assay and the IC(50) was calculated. At non-cytotoxic concentrations, the viability of cells decreased with increase of concentration of plant extract. The anti-proliferative effect was also found to be dose-dependent. Analysis via flow cytometry shows that marjoram extracts stimulated apoptosis. Induction of apoptosis was caused by an up-regulation of p53 protein levels and down-regulation of Bcl-2alpha. Marjoram exhibited a strong scavenging activity (SC(50)=0.03mg dry weight). The conclusions from this study suggest that marjoram extracts exhibit anti-proliferative effect and high antioxidant activity. For that it merits further investigation as a potential therapeutic agent.

PMID:
19853912
DOI:
10.1016/j.leukres.2009.09.018
[Indexed for MEDLINE]

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