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Dev Cell. 2009 Oct;17(4):435-7. doi: 10.1016/j.devcel.2009.10.004.

More than a pipe dream: uncovering mechanisms of vascular lumen formation.

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  • 1Northwestern University, Department of Molecular Biology and Cell Biology, Evanston, IL 60208, USA.

Abstract

An unresolved question in vasculogenesis is how mammalian endothelial cells make lumens in developing vessels. In this issue of Developmental Cell, Strilic et al. present a comprehensive analysis of murine arterial lumen formation that defines cellular and molecular events required for lumen morphogenesis and argues against a previous paradigm of lumen formation.

PMID:
19853555
DOI:
10.1016/j.devcel.2009.10.004
[PubMed - indexed for MEDLINE]
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