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J Org Chem. 2009 Nov 20;74(22):8870-3. doi: 10.1021/jo901835m.

Multi-gram scale synthesis of FR180204.

Author information

1
National Institutes of Health Chemical Genomics Center, 9800 Medical Center Drive, Rockville, Maryland 20850, USA. patnaiks@mail.nih.gov

Abstract

A concise synthesis of the ERK inhibitor FR180204 has been developed. The synthesis consists of six operationally simple steps and can be utilized to make multi-gram quantities of FR180204.

PMID:
19852504
PMCID:
PMC2862695
DOI:
10.1021/jo901835m
[Indexed for MEDLINE]
Free PMC Article

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