Format

Send to

Choose Destination
See comment in PubMed Commons below
Metab Brain Dis. 2009 Dec;24(4):673-84. doi: 10.1007/s11011-009-9169-y. Epub 2009 Oct 23.

Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins.

Author information

1
Molecular Medicine Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. rouault@mail.nih.gov

Abstract

Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.

PMID:
19851851
PMCID:
PMC2788140
DOI:
10.1007/s11011-009-9169-y
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center