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Nat Rev Cancer. 2009 Nov;9(11):773-84. doi: 10.1038/nrc2736.

Polycomb group proteins: navigators of lineage pathways led astray in cancer.

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1
The Smurfit Institute of Genetics, Trinity College Dublin and The Adelaide & Meath Hospital, including the National Children's Hospital, Dublin, Ireland. adrian.bracken@tcd.ie

Abstract

The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.

PMID:
19851313
DOI:
10.1038/nrc2736
[Indexed for MEDLINE]
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