Format

Send to

Choose Destination
Curr Opin Pharmacol. 2010 Feb;10(1):23-9. doi: 10.1016/j.coph.2009.09.010. Epub 2009 Oct 21.

The role of dimerisation in the cellular trafficking of G-protein-coupled receptors.

Author information

1
Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK. g.milligan@bio.gla.ac.uk

Abstract

The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate. Use of endoplasmic reticulum trapping strategies and the generation of asymmetric homomers have started to provide information on the contribution of protein-protein interactions to receptor maturation, cell surface delivery and ligand-mediated endocytosis. Although dimer/oligomer formation appears to be essential for cell surface delivery of class A and class C GPCRs, this may not be the case for class B receptors.

PMID:
19850521
DOI:
10.1016/j.coph.2009.09.010
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center