Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Obstet Gynecol Reprod Biol. 2010 Jan;148(1):56-61. doi: 10.1016/j.ejogrb.2009.09.015.

Perinatal outcome in singletons after modified natural cycle IVF and standard IVF with ovarian stimulation.

Author information

1
Section of Reproductive Medicine, Department of Obstetrics and Gynaecology, University Medical Center Groningen, PO Box 30001, 9700RB Groningen, The Netherlands. pelinck@hotmail.com

Abstract

OBJECTIVE:

Singletons born after IVF treatment are at risk for adverse pregnancy outcome, the cause of which is unknown. The aim of the present study was to investigate the influence of ovarian stimulation on perinatal outcome.

STUDY DESIGN:

In this single-centre retrospective study, perinatal outcome of singleton pregnancies resulting from IVF treatment with (n=106) and without ovarian stimulation (n=84) were compared. For IVF without ovarian stimulation, a modified natural cycle protocol was used.

RESULTS:

No differences were found in pregnancy duration, proportion of prematurity and proportion of low birth weight. Mean birth weight of modified natural cycle vs standard IVF singletons was 3485 (+/-527) vs 3218 (+/-670)g; P=0.003. After adjustment for prognostic factors by linear regression analysis, the difference in birth weight remaining was 134 g; P=0.045.

CONCLUSIONS:

Birth weights of modified natural cycle IVF singletons found in this study are higher than standard IVF singletons, suggesting that ovarian stimulation may be a causative factor in the occurrence of low birth weight in standard IVF.

PMID:
19850400
DOI:
10.1016/j.ejogrb.2009.09.015
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center