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Clin Biochem. 2010 Feb;43(3):317-9. doi: 10.1016/j.clinbiochem.2009.10.005. Epub 2009 Oct 20.

Serum levels of vascular endothelial growth factor and its receptors in patients with severe autism.

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1
Department of Health Sciences, Section of Psychiatry, University of Pavia, Via Bassi, 21, I-27100, Pavia, Italy. enzo.em@libero.it

Abstract

OBJECTIVE:

To study vascular endothelial growth factor (VEGF) and its soluble receptors sVEGFR-1 and -2 in autism.

DESIGN AND METHODS:

We measured serum levels of angiogenic molecules in 22 patients with severe autism and 28 controls.

RESULTS:

Patients and controls had similar sVEGFR-2 levels, but VEGF levels were lower and sVEGFR-1 higher in patients with autism.

CONCLUSION:

The imbalance between VEGF and its receptor sVEGFR-1 may be involved in the pathophysiology of autism.

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