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Infect Control Hosp Epidemiol. 2009 Dec;30(12):1218-22. doi: 10.1086/648082.

Annual incidence of latent tuberculosis infection among newly employed nurses at a tertiary care university hospital.

Author information

1
Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Korea.

Abstract

OBJECTIVE:

To investigate the annual rate of tuberculosis (TB) infection among newly employed nurses using both tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT-G; Cellestis Limited) assay.

DESIGN:

A prospective cohort study involving newly employed nurses.

SETTING:

A tertiary care university hospital in South Korea.

METHODS:

All participants (n = 196) were tested with the TST and QFT-G assay at baseline. After 1 year, the TST and QFT-G assay were reperformed for subjects who had negative TST results at baseline and for all subjects, respectively.

RESULTS:

The baseline TST and QFT-G assays were positive for 101 subjects (51.5%) and 28 subjects (14.3%), respectively; 22 subjects (11.2%) had positive results of both tests. Although the overall between-test agreement was 54.9% (k = 0.151) [95% confidence interval, 0.047-0.245]), agreement improved to 78.5% (k = 0.462 [95% confidence interval, 0.007-0.917]) for subjects who had not received bacille Calmette-Guérin vaccination. After 1 year, the TST yielded positive results for 16 (21.3%) of 75 nurses with negative baseline results, and the QFT-G assay yielded positive results for 21 (14.4%) of 146 subjects with negative baseline results. Collectively, 5 subjects (3.0%) experienced conversion to positive results with both tests, and 32 subjects (18.9%) experienced conversion to positive results with one of the tests. Neither the employing hospital department nor exposure to patients with TB affected test conversion status.

CONCLUSIONS:

The poor overall agreement between TST and QFT-G results may have been caused by the confounding effect of bacille Calmette-Guérin vaccination. The annual risk of TB infection among newly employed nurses was at least 3% on the basis of results of both the TST and QFT-G test. Stricter preventive strategies against TB spread should be implemented in our hospital.

PMID:
19848602
DOI:
10.1086/648082
[Indexed for MEDLINE]

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