Format

Send to

Choose Destination
Chem Soc Rev. 2009 Nov;38(11):2993-3009. doi: 10.1039/b903290h. Epub 2009 Apr 21.

The art of total synthesis through cascade reactions.

Author information

1
The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. kcn@scripps.edu

Abstract

The growing importance of cascade reactions reflects and imparts advances in the state of the art of organic synthesis and underscores the desire of synthetic chemists to achieve higher levels of elegance and efficiency. Besides their esthetic appeal, cascade processes offer economical and environmentally friendly means for generating molecular complexity. Because of their many advantages, these reactions have found numerous applications in the synthesis of complex molecules, both natural and designed. In this tutorial review, we highlight the design and execution of cascade reactions within the context of total synthesis as demonstrated with selected examples from these laboratories.

PMID:
19847336
PMCID:
PMC2766600
DOI:
10.1039/b903290h
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Royal Society of Chemistry Icon for PubMed Central
Loading ...
Support Center