Abstract
Although the normal glomerulus comprises four resident cell types, least is known about the parietal epithelial cells (PECs). This comprehensive review addresses the cellular origin of PECs, discusses the normal structure and protein makeup of PECs, describes PEC function, and defines the responses to injury in disease and how these events lead to clinical events. The data show that PECs have unique properties and that new functions are being recognized such as their role in differentiating into podocytes during disease.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Apoptosis
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Biomarkers / metabolism
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Cell Differentiation
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Cell Proliferation
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Disease Models, Animal
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Epithelial Cells / cytology
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Epithelial Cells / metabolism
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Humans
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Kidney Diseases / etiology
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Kidney Diseases / pathology
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Kidney Diseases / physiopathology
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Kidney Glomerulus / cytology*
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Kidney Glomerulus / growth & development
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Kidney Glomerulus / metabolism
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Models, Biological
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Permeability
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Podocytes / cytology
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Podocytes / metabolism
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Proteins / metabolism