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J Pediatr. 2010 Feb;156(2):292-5. doi: 10.1016/j.jpeds.2009.08.047. Epub 2009 Oct 20.

Long-term clinical significance of thyroid autoimmunity in children with celiac disease.

Author information

1
Department of Pediatrics, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy. alessandra.cassio@unibo.it

Abstract

OBJECTIVE:

To evaluate the long-term outcome of thyroid function and autoimmunity in a large series of children with celiac disease.

STUDY DESIGN:

This longitudinal, retrospective study (duration of follow-up, 8.9 +/- 4.0 years) was conducted at the Pediatric Department, University of Bologna, Italy. One hundred thirty-five consecutive patients diagnosed between June 1990 and December 2004 and followed on a gluten-free diet were examined. Inclusion criteria were good dietary compliance and duration of follow-up for at least 3 years.

RESULTS:

Of 101 patients who never showed positive antithyroid titers during the follow-up, 86 remained euthyroid; 15 showed high thyroid-stimulating hormone values at diagnosis that normalized in 11 cases after 12 to 18 months of gluten withdrawal. Of 31 patients with persistently positive antibody titers, 23 (74%) remained consistently euthyroid during the follow-up and 8 (26%) had a subclinical hypothyroidism. The prevalence of cases with positive antibodies was similar in children with growth retardation or gastroenterological symptoms at diagnosis and different durations of gluten exposure.

CONCLUSIONS:

The presence of antithyroid antibodies in children with celiac disease has a low predictive value for the development of thyroid hypofunction during the indicated surveillance period. Longer follow-up is needed.

PMID:
19846116
DOI:
10.1016/j.jpeds.2009.08.047
[Indexed for MEDLINE]

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