Format

Send to

Choose Destination
Ann Intern Med. 1991 Jan 15;114(2):147-50.

Caffeine and cardiac arrhythmias.

Author information

1
Division of Cardiology, Sunnybrook Health Science Centre, Toronto, Ontario.

Abstract

PURPOSE:

To review the evidence supporting the belief that caffeine causes cardiac arrhythmias.

DATA SOURCES:

Studies published since 1982 identified through computerized searches of MEDLINE, TOXLINE, and Chemical Abstracts and a review of bibliographies of relevant articles on the subject of caffeine and cardiac arrhythmias.

STUDY SELECTION:

All clinical studies examining caffeine as a cause of cardiac arrhythmias and a selection of basic science experiments to illustrate caffeine's effects in vitro.

DATA EXTRACTION:

Study quality was assessed and all available clinical data pertaining to caffeine as a cause of arrhythmias were summarized.

RESULTS OF DATA ANALYSIS:

In one electrophysiologic study, caffeine was associated with an increased susceptibility to provoked cardiac arrhythmias. In five placebo-controlled trials, caffeine in doses up to 500 mg daily (equivalent to 5 to 6 cups of coffee) did not increase the frequency or severity of ventricular arrhythmias. One large epidemiologic study reported an increase in the frequency of ventricular extrasystoles in persons consuming 9 or more cups of coffee daily.

CONCLUSION:

Moderate ingestion of caffeine does not increase the frequency or severity of cardiac arrhythmias in normal persons, patients with ischemic heart disease, or those with pre-existing serious ventricular ectopy.

PMID:
1984393
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center