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Nat Chem Biol. 2009 Nov;5(11):815-22. doi: 10.1038/nchembio.250.

Targeting proteins for degradation.

Author information

1
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA.

Erratum in

  • Nat Chem Biol. 2009 Dec;5(12):954.

Abstract

Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response. In eukaryotic cells, an ATP-dependent protease called the proteasome is responsible for much of this proteolysis. Proteins are targeted for proteasomal degradation by a two-part degron, which consists of a proteasome binding signal and a degradation initiation site. Here we describe how both components contribute to the specificity of degradation.

PMID:
19841631
PMCID:
PMC4228941
DOI:
10.1038/nchembio.250
[Indexed for MEDLINE]
Free PMC Article

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