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Neuron. 2009 Oct 15;64(1):40-5. doi: 10.1016/j.neuron.2009.09.044.

MHC class I: an unexpected role in neuronal plasticity.

Author information

1
Bio-X and Departments of Biology and Neurobiology, James H. Clark Center, 318 Campus Drive W1.1, Stanford University, Stanford CA 94305-5437, USA. cshatz@stanford.edu

Abstract

For the nervous system to translate experience into memory and behavior, lasting structural change at synapses must occur. This requirement is clearly evident during critical periods of activity-dependent neural development, and accumulating evidence has established a surprising role for the major histocompatibility complex class I (MHCI) proteins in this process.

PMID:
19840547
PMCID:
PMC2773547
DOI:
10.1016/j.neuron.2009.09.044
[Indexed for MEDLINE]
Free PMC Article

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