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J Laryngol Otol. 2010 Jan;124(1):32-6. doi: 10.1017/S0022215109991435. Epub 2009 Oct 20.

Prospective study of sensorineural hearing loss following radiotherapy for nasopharyngeal carcinoma.

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1
Department of Otolaryngology, Head and Neck Surgery and the Institute of Otology, the Second Xiangya Hospital, Central South University, Hunan, People's Republic of China.

Abstract

OBJECTIVES:

To investigate the severity and incidence of sensorineural hearing loss in patients with nasopharyngeal carcinoma treated with radiotherapy.

METHODS:

Forty-two patients with nasopharyngeal carcinoma were treated with conventional radiotherapy. Audiological testing was performed to compare patients' hearing before and at varying stages after radiotherapy.

RESULTS:

At one month post-radiation, a significant hearing threshold increase was seen only for high frequencies. At 12, 24 and 60 months post-radiation, significant threshold increases were observed at speech frequencies (4.0 and 8.0 kHz), compared with pre-radiation data. The mean values of wave I, III and V latencies and of the I-V interpeak latency intervals were not significantly altered at one month post-radiation, but were significantly prolonged at 12, 24 and 60 months post-radiation, compared with pre-radiation data.

CONCLUSION:

In patients with nasopharyngeal carcinoma treated with radiotherapy, the severity and incidence of radiation-induced sensorineural hearing loss increased with time, especially at high frequencies. This hearing impairment may be due to changes in the cochlea and/or the retrocochlear auditory pathway.

PMID:
19840426
DOI:
10.1017/S0022215109991435
[Indexed for MEDLINE]
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