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Clin Infect Dis. 2009 Nov 15;49(10):1565-9. doi: 10.1086/644733.

Bordetella pertussis and pertussis vaccines.

Author information

1
Institut Pasteur, Molecular Prevention and Therapy of Human Diseases, Paris, France. nicole.guiso@pasteur.fr

Abstract

Bordetella pertussis is a human-specific pathogen that causes whooping cough. The use of pertussis whole-cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life-long immunity; indeed, the circulation of the bacterium has not been controlled in the adult population. Universal adult booster immunization is now possible using pertussis acellular vaccines, which target-and are thus likely to control-the virulence of this bacterium.

PMID:
19839747
DOI:
10.1086/644733
[Indexed for MEDLINE]

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