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Nutr Cancer. 2009;61(5):746-53. doi: 10.1080/01635580902825597.

Stearate preferentially induces apoptosis in human breast cancer cells.

Author information

1
University of Alabama at Birmingham, Birmingham, Alabama, USA.

Abstract

Stearic acid (stearate) is an 18-carbon saturated fatty acid that has been shown to inhibit invasion and proliferation and induce apoptosis in various human cell types. The specificity of stearate-induced apoptosis for cancerous versus noncancerous breast cells has not been examined, and the mechanism underlying stearate-induced apoptosis is unknown. Morphological analysis, cell viability, and caspase-3 activity assays demonstrated that stearate activated apoptosis preferentially in cancerous breast cells in a time- and dose-dependent manner. Inhibition of de novo diacylgycerol synthesis or protein kinase C (PKC) blocked stearate-induced caspase-3 activity, indicating the involvement of a novel or classical PKC isozyme. To our knowledge this is the first study showing that stearate induces apoptosis preferentially in breast cancer cells and implicates protein kinase C in the signaling cascade. These results raise the possibility of dietary stearate having a beneficial role in the prevention or treatment of breast cancer.

PMID:
19838949
PMCID:
PMC2946230
DOI:
10.1080/01635580902825597
[Indexed for MEDLINE]
Free PMC Article

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