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Nat Neurosci. 2009 Nov;12(11):1361-3. doi: 10.1038/nn.2432. Epub 2009 Oct 18.

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.

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1
Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Abstract

In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.

PMID:
19838177
PMCID:
PMC4721582
DOI:
10.1038/nn.2432
[Indexed for MEDLINE]
Free PMC Article

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