Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2009 Nov;12(11):1361-3. doi: 10.1038/nn.2432. Epub 2009 Oct 18.

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.

Author information

1
Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Abstract

In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.

PMID:
19838177
PMCID:
PMC4721582
DOI:
10.1038/nn.2432
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center