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Nat Methods. 2009 Nov;6(11):805-8. doi: 10.1038/nmeth.1393. Epub 2009 Oct 18.

A chemical platform for improved induction of human iPSCs.

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1
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.

Abstract

The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.

PMID:
19838168
PMCID:
PMC3724527
DOI:
10.1038/nmeth.1393
[Indexed for MEDLINE]
Free PMC Article
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