Abstract
The Drosophila immune deficiency (IMD) signaling cascade regulates the IKK/NF-kappaB signaling cassette and shares striking similarities with the mammalian TNF-R1 pathway. Thevenon et al. (2009) reveal how dUSP36, a deubiquitinating enzyme of the ubiquitin-specific protease (USP) family, prevents the constitutive activation of the IMD pathway by resident gut bacteria.
MeSH terms
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Animals
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Bacteria / immunology*
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Drosophila / immunology*
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Drosophila Proteins / immunology*
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Endopeptidases / immunology*
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Gastrointestinal Tract / microbiology*
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Immunologic Factors / immunology*
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Models, Biological
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NF-kappa B / antagonists & inhibitors*
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NF-kappa B / immunology*
Substances
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Drosophila Proteins
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Immunologic Factors
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NF-kappa B
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Endopeptidases
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ubiquitin specific protease 36, Drosophila