Tuning down NF-kappaB signaling by DUBs: a fly case

Cell Host Microbe. 2009 Oct 22;6(4):294-6. doi: 10.1016/j.chom.2009.10.002.

Abstract

The Drosophila immune deficiency (IMD) signaling cascade regulates the IKK/NF-kappaB signaling cassette and shares striking similarities with the mammalian TNF-R1 pathway. Thevenon et al. (2009) reveal how dUSP36, a deubiquitinating enzyme of the ubiquitin-specific protease (USP) family, prevents the constitutive activation of the IMD pathway by resident gut bacteria.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bacteria / immunology*
  • Drosophila / immunology*
  • Drosophila Proteins / immunology*
  • Endopeptidases / immunology*
  • Gastrointestinal Tract / microbiology*
  • Immunologic Factors / immunology*
  • Models, Biological
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / immunology*

Substances

  • Drosophila Proteins
  • Immunologic Factors
  • NF-kappa B
  • Endopeptidases
  • ubiquitin specific protease 36, Drosophila