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Cell. 2009 Oct 16;139(2):246-64. doi: 10.1016/j.cell.2009.09.029.

Phototransduction motifs and variations.

Author information

1
Solomon H. Snyder Department of Neuroscience and Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. kwyau@mail.jhmi.edu

Abstract

Seeing begins in the photoreceptors, where light is absorbed and signaled to the nervous system. Throughout the animal kingdom, photoreceptors are diverse in design and purpose. Nonetheless, phototransduction-the mechanism by which absorbed photons are converted into an electrical response-is highly conserved and based almost exclusively on a single class of photoproteins, the opsins. In this Review, we survey the G protein-coupled signaling cascades downstream from opsins in photoreceptors across vertebrate and invertebrate species, noting their similarities as well as differences.

PMID:
19837030
PMCID:
PMC2885920
DOI:
10.1016/j.cell.2009.09.029
[Indexed for MEDLINE]
Free PMC Article
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