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Cell. 2009 Oct 16;139(2):231-3. doi: 10.1016/j.cell.2009.09.030.

Structure casts light on mtDNA replication.

Author information

1
Department of Medical Biochemistry and Cell Biology, Göteborg University, SE-405 30 Göteborg, Sweden. maria.falkenberg@medkem.gu.se

Abstract

In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.

PMID:
19837028
DOI:
10.1016/j.cell.2009.09.030
[Indexed for MEDLINE]
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