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Bioorg Med Chem Lett. 2009 Dec 1;19(23):6706-8. doi: 10.1016/j.bmcl.2009.09.118. Epub 2009 Oct 3.

Solid phase synthesis of acylglycine human metabolites.

Author information

1
Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada. perezpin@ualberta.ca

Abstract

Acylglycines represents a large and important class of human metabolites. They are often used in medicine to identify fatty acid oxidation disorders. A highly efficient solid phase synthesis approach to obtain these clinically important compounds is developed via coupling reaction between glycine-preloaded Wang resin and a set of carboxylic acids. The developed methodology facilitates the preparation of several structurally-diverse acylglycines with high yields and purity.

PMID:
19836947
DOI:
10.1016/j.bmcl.2009.09.118
[Indexed for MEDLINE]

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