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Curr Opin Struct Biol. 2009 Dec;19(6):666-71. doi: 10.1016/j.sbi.2009.09.004.

Adenylate-forming enzymes.

Author information

1
Scottish Structural Proteomics Facility and Biomedical Science Research Complex, The University of St Andrews, Scotland KY16 9ST, UK.

Abstract

Thioesters, amides, and esters are common chemical building blocks in a wide array of natural products. The formation of these bonds can be catalyzed in a variety of ways. For chemists, the use of an activating group is a common strategy and adenylate enzymes are exemplars of this approach. Adenylating enzymes activate the otherwise unreactive carboxylic acid by transforming the normal hydroxyl leaving group into adenosine monophosphate. Recently there have been a number of studies of such enzymes and in this review we suggest a new classification scheme. The review highlights the diversity in enzyme fold, active site architecture, and metal coordination that has evolved to catalyze this particular reaction.

PMID:
19836944
PMCID:
PMC3313645
DOI:
10.1016/j.sbi.2009.09.004
[Indexed for MEDLINE]
Free PMC Article

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