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Curr Opin Cell Biol. 2009 Dec;21(6):796-805. doi: 10.1016/j.ceb.2009.09.008.

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins.

Author information

1
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Edinburgh, Scotland, UK. mar.carmena@ed.ac.uk

Abstract

The conserved Aurora family of protein kinases have emerged as crucial regulators of mitosis and cytokinesis. Despite their high degree of homology, Aurora A and B have very distinctive localisations and functions: Aurora A associates with the spindle poles to regulate entry into mitosis, centrosome maturation and spindle assembly; Aurora B is a member of the Chromosomal Passenger Complex (CPC) that transfers from the inner centromere in early mitosis to the spindle midzone, equatorial cortex and midbody in late mitosis and cytokinesis. Aurora B functions include regulation of chromosome-microtubule interactions, cohesion, spindle stability and cytokinesis. This review will focus on how interacting proteins make this functional diversity possible by targeting the kinases to different subcellular locations and regulating their activity.

PMID:
19836940
PMCID:
PMC2806521
DOI:
10.1016/j.ceb.2009.09.008
[Indexed for MEDLINE]
Free PMC Article
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