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Trends Pharmacol Sci. 2009 Dec;30(12):624-30. doi: 10.1016/

Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies.

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Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.


Identification and characterization of VEGF as an important regulator of angiogenesis, and FDA approval of the first anti-angiogenic drugs, has enabled significant advances in the therapy of cancer and neovascular age-related macular degeneration. However, similar to other therapies, inherent/acquired resistance to anti-angiogenic drugs may occur in patients, leading to disease recurrence. Recent studies in several experimental models suggest that tumor and non-tumor (stromal) cell types may be involved in the reduced responsiveness to the treatments. The present review examines the role of tumor- as well as stromal cell-derived pathways involved in tumor growth and in refractoriness to anti-VEGF therapies.

[Indexed for MEDLINE]

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