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Can J Psychiatry. 2009 Oct;54(10):665-72.

The restless brain: attention-deficit hyperactivity disorder, resting-state functional connectivity, and intrasubject variability.

Author information

1
Neidich Professor of Child and Adolescent Psychiatry, Phyllis Green and Randolph Côwen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, New York, USA. francisco.castellanos@nyumc.org

Abstract

OBJECTIVES:

To highlight recent advances in the conceptualization of attention-deficit hyperactivity disorder (ADHD) emerging from neuroimaging and endophenotypic approaches.

METHODS:

We selectively reviewed recent published literature on the phenomena of resting-state functional connectivity, intrasubject variability, and diffusion tensor imaging pertaining to ADHD.

RESULTS:

Recent advances based on the novel approach of resting-state functional connectivity appear to be highly promising and likely to link to studies of intrasubject variability.

CONCLUSIONS:

Endophenotypic fractionation may offer a means of addressing the complex heterogeneity of ADHD on the path to testable models of pathophysiology. Such models focusing on intrasubject variability, intrinsic brain activity, and reward-related processing are progressing rapidly.

PMID:
19835673
PMCID:
PMC3876940
DOI:
10.1177/070674370905401003
[Indexed for MEDLINE]
Free PMC Article

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