Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Microbiol. 2009 Nov;7(11):798-812. doi: 10.1038/nrmicro2223.

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs.

Author information

1
AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain. mcoiras@isciii.es

Abstract

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs are established early during primary infection and constitute a major barrier to eradication, even in the presence of highly active antiretroviral therapy. This Review analyses the molecular mechanisms that are necessary for the establishment of HIV-1 latency and their relationships with different cellular and anatomical reservoirs, and discusses the current treatment strategies for targeting viral persistence in reservoirs, their main limitations and future perspectives.

PMID:
19834480
DOI:
10.1038/nrmicro2223
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center