Format

Send to

Choose Destination
Genes Dev. 2009 Oct 15;23(20):2376-81. doi: 10.1101/gad.1836009.

Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.

Author information

1
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA. minlay@stanford.edu

Erratum in

  • Genes Dev. 2013 Sep 15;27(18):2063.

Abstract

Common lymphoid progenitors (CLPs) clonally produce both B- and T-cell lineages, but have little myeloid potential in vivo. However, some studies claim that the upstream lymphoid-primed multipotent progenitor (LMPP) is the thymic seeding population, and suggest that CLPs are primarily B-cell-restricted. To identify surface proteins that distinguish functional CLPs from B-cell progenitors, we used a new computational method of Mining Developmentally Regulated Genes (MiDReG). We identified Ly6d, which divides CLPs into two distinct populations: one that retains full in vivo lymphoid potential and produces more thymocytes at early timepoints than LMPP, and another that behaves essentially as a B-cell progenitor.

PMID:
19833765
PMCID:
PMC2764492
DOI:
10.1101/gad.1836009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center