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Genes Dev. 2009 Oct 15;23(20):2359-65. doi: 10.1101/gad.1860609.

HARPing on about the DNA damage response during replication.

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1
Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305, USA.

Abstract

In this issue of Genes & Development, four papers report that the annealing helicase HepA-related protein (HARP, also known as SMARCAL1 [SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1]) binds directly to the ssDNA-binding protein Replication protein A (RPA) and is recruited to sites of replicative stress. Knockdown of HARP results in hypersensitivity to multiple DNA-damaging agents and defects in fork stability or restart. These exciting insights reveal a key new player in the S-phase DNA damage response.

PMID:
19833762
PMCID:
PMC2764495
DOI:
10.1101/gad.1860609
[Indexed for MEDLINE]
Free PMC Article
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