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Discov Med. 2009 Oct;8(42):151-6.

Natural autoantibodies to apoptotic cell membranes regulate fundamental innate immune functions and suppress inflammation.

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Medicine, University of California San Diego, La Jolla, California 92024-0663, United States.


The evolution of the immune system has provided a multilevel system that interconnects the innate and adaptive immune systems to serve at least three central purposes: the defense from microbial pathogens, the capacity for discrimination of self- from non-self necessary for the prevention of autoimmune disease, and essential effector roles in wound repair and tissue remodeling. In recent studies, we have elucidated an unsuspected role for a class of naturally occurring autoreactive antibodies from the most primitive tier of B lymphocytes, which regulates fundamental functions of the innate immune system. Our findings also throw light onto long unresolved mysteries regarding the origins of the earliest waves of B lymphocyte development.

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