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Int J Sports Med. 2009 Nov;30(11):775-8. doi: 10.1055/s-0029-1234058. Epub 2009 Oct 14.

Nandrolone inhibits VEGF mRNA in rat muscle.

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Universidade Federal de São Carlos, Ciências Fisiológicas, São Carlos, Brazil.


Vascular endothelial growth factor (VEGF) is a key compound for induction of angiogenesis in both physiological and pathological conditions. The aim of this study was to investigate the effect of androgenic-anabolic steroids (AAS) administration on VEGF mRNA expression in the rat soleus muscle after jumping training. Wistar rats were grouped into: sedentary (S); nandrolone decanoate-treated sedentary (AAS); trained without AAS (T) and trained and treated with AAS (AAST). Exercised groups performed a 7-weeks water-jumping program. Animals killed immediately after the last exercise bout showed significantly increased VEGF mRNA expression; however, the AAS treatment completely inhibited this effect. These results suggest that the AAS may be strongly prejudicial to muscle remodeling and performance at least partially due to an impaired angiogenesis.

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